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TOPICS BONOBO Chimpanzee "Ai" Crania photos Itani Jun'ichiro archives Open datasets for behavioral analysis Guidelines for Care and Use of Nonhuman Primates(pdf) Study material catalogue/database Guideline for field research of non-human primates 2019(pdf) Primate Genome DB 
Primate Research Institute, Kyoto University Copyright (c) |
Japanese Expression of Bitter Taste Receptors in the Intestinal Cells of Non-Human Primates
Hiroo Imai, Miho Hakukawa, Misa Hayashi, Ken Iwatsuki, Katsuyoshi Masuda
Abstract
(1) Background: Recent studies have investigated the expression of taste-related genes in the organs of various animals, including humans; however, data for additional taxa are needed to facilitate comparative analyses within and among species. (2) Methods: We investigated the expression of taste-related genes in the intestines of rhesus macaques, the non-human primates most commonly used in experimental models. (3) Results: Based on RNAseq and qRT-PCR, genes encoding bitter taste receptors and the G-protein gustducin were expressed in the gut of rhesus macaques. RNAscope analysis showed that one of the bitter receptors, TAS2R38, was expressed in some cells in the small intestine, and immunohistochemical analysis revealed the presence of T2R38-positive cells in the villi of the intestines. (4) Conclusions: These results suggest that bitter receptors are expressed in the gut of rhesus macaques, supporting the use of macaques as a model for studies of human taste, including gut analyses. Bibliographic information
Int. J. Mol. Sci. 2020, 21(3), 902; https://doi.org/10.3390/ijms21030902 https://www.mdpi.com/1422-0067/21/3/902 2020/02/04 Primate Research Institute
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