Direct estimation of de novo mutation rates in a chimpanzee parent-offspring trio by ultra-deep whole genome sequencing.

Shoji Tatsumoto, Yasuhiro Go, Kentaro Fukuta, Hideki Noguchi, Takashi Hayakawa, Masaki Tomonaga, Hirohisa Hirai, Tetsuro Matsuzawa, Kiyokazu Agata & Asao Fujiyama

Abstract

We determined the unprecedented amount of whole genome sequences from a chimpanzee parent-offspring trio and disclosed the precise mutation rates and modes through the transmission of genomes from parents to offspring. Through the transmission of genomes, very rare but a certain frequency of de novo (new) mutations have occurred (illustrated in the figure as 'T' in the father chromosome substitute to 'C' in the inherited chromosome in offspring). About 75% of this type of mutation has occurred in the paternally-derived germline cells (male-biased mutation).

Bibliographic information

Scientific Reports 7, Article number: 13561 (2017)
doi:10.1038/s41598-017-13919-7

2017/11/02 Primate Research Institute