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Hypoxemia after single-shot anesthesia in common marmosets
Naho Konoike, Miki Miwa, Akiyo Ishigami, Katsuki Nakamura

It remains unknown how single-shot anesthesia influences physical
parameters, especially respiratory function and blood oxygen level of
common marmosets (Callithrix jacchus) which came to be used for
laboratory research.

We measured blood oxygen levels, both before and after oxygenation, in
13 common marmosets under two single-shot anesthesia conditions:
ketamine/xylazine/atropine and alphaxalone.

We found that SpO2 values decreased to about 80% in the
ketamine/xylazine/atropine protocol and fell just below 90% in the
alphaxalone protocol. We observed a clear decrease in PaO2 values under
the anesthetized condition compared to the awake condition. Our data
indicate that single-shot anesthesia may cause hypoxemia in marmosets.
Previous studies on other non-human primate have reported no SpO2
decrease and hypoxemia; thus, our experiment suggests that marmosets may
have a more fragile respiratory system and require intensive veterinary
care during anesthesia.
Journal of Medical Primatology 2017;00:1-5
doi: 10.1111/jmp.12262
2017/04/08 Primate Research Institute