JAPANESE TOP Message from the Director Information Faculty list Research Cooperative Research Projects Entrance Exam Publication Job Vacancy INTERNSHIP PROGRAM Links Access HANDBOOK FOR INTERNATIONAL RESEARCHERS Map of Inuyama
BONOBO Chimpanzee "Ai" Crania photos Itani Jun'ichiro archives Open datasets for behavioral analysis Guidelines for Care and Use of Nonhuman Primates(pdf) Study material catalogue/database Guideline for field research of non-human primates 2019(pdf) Primate Genome DB

Primate Research Institute, Kyoto University
Inuyama, Aichi 484-8506, JAPAN
TEL. +81-568-63-0567
(Administrative Office)
FAX. +81-568-63-0085

Copyright (c)
Primate Research Institute,
Kyoto University All rights reserved.



Common marmoset (Callithrix jacchus) as a primate model of dengue virus infection: development of high levels of viremia and demonstration of protective immunity.

Omatsu T, Moi ML, Hirayama T, Takasaki T, Nakamura S, Tajima S, Ito M, Yoshida T, Saito A, Katakai Y, Akari H*, Kurane I* (* co-corresponding authors)

Dengue virus (DENV) causes a wide range of illness in humans: dengue fever, dengue hemorrhagic fever and dengue shock syndrome. Animal models that constantly develop high levels of viremia are required for the development of protective and preventive measures. Common marmosets (Callithrix jacchus) demonstrated high levels of viremia after inoculation with DENV; in particular, over 10-E6 genome copies/ml after inoculation with DENV-2. Nonstructural protein 1 and DENV-specific IgM and IgG were consistently detected. DENV-2 genome was detected in lymphoid organs such as the lymph nodes, spleen and thymus, and also in non-lymphoid organs. DENV antigen was detected by immunochemistry in liver and spleen from inoculated marmosets. Four marmosets were inoculated with DENV-2 at 33 weeks after primary inoculation with DENV-2. DENV-2 genome was not detected in any of these marmosets, indicating protection from secondary infection. The results indicate that common marmosets are highly sensitive to DENV infection, and suggest that marmosets could be a reliable primate model for evaluation of candidate vaccines.

J Gen Virol. 2011 Jun 22. [Epub ahead of print]


Copyright(C) 2010 PRI (). All rights reserved.